For instance, miR-103a-3p mediates TNF-α-induced synovial inflammation and bone erosion by targeting MAP3K7 and DKK1 50, while miR-548aj-3p and miR-3127-3p attenuate RANKL-driven expression of pro-inflammatory cytokines and matrix-degrading enzymes in both osteoarthritis and RA 51. This evidence concerns the gene DKK1 and rheumatoid arthritis.