During tumor progression, cancer cells and cells within the tumor microenvironment (TME) produce lymphangiogenic factors—such as vascular endothelial growth factor (VEGF)-C, fibroblast growth factor (FGF)-2, and platelet-derived growth factor (PDGF)-BB—that attract lymphatic endothelial cells (LECs) to infiltrate the tumor tissues, resulting in the formation of new lymphatic vessels within and around the tumor. This evidence concerns the gene VEGFC and neoplasm.