PRIMPOL and cancer: Besides, USP35, USP36, and USP47 have been shown to promote cancer cell proliferation and development by interacting and deubiquitinating ribosome-binding protein 1 (RRBP1), primase and DNA directed polymerase (PrimPol), and BTB and CNC homology 1 (BACH1), mitigating ER stress-induced apoptosis and DNA replication stress caused by cisplatin and promoting Warburg effect, respectively 33-35.