These included stellate cell activation and liver fibrosis, multiple TGF-β-driven programs (stimulation in lung, breast, pancreatic, and colorectal cancers; SMAD signaling; Activin A signaling; and EMT induction), and EGFR- and WNT/β-catenin-mediated transcriptional regulation. This evidence concerns the gene TGFB1 and colorectal cancer.