Analysis of the GEO dataset (GSE218035) revealed that LOXL1, LOXL2, and LOXL3 expression levels were significantly elevated in osteosarcoma tissues compared to normal bone tissues (p < 0.01), whereas no significant difference was observed for LOXL4 expression (Fig. 2A-E). This evidence concerns the gene LOXL3 and osteosarcoma.