Notably, miR-4463 has also been reported to promote proliferation and migration while inhibiting apoptosis in colorectal cancer by targeting PPP1R12B, suggesting a broader oncogenic role across tumor types; our findings extend this concept by demonstrating that in osteosarcoma, FGF-23 upregulates LOXL2 via suppression of miR-4463, thereby enhancing metastatic potential 45. This evidence concerns the gene LOXL2 and osteosarcoma.