In the MCAO/R model, a specific TRPV2 negative allosteric modulator plumbagin reduces cerebral infarction and neurological deficit by anti‐inflammatory polarization of microglia, evidenced by increasing transcript levels of anti‐inflammatory factors Arg1, Il‐10, and transforming growth factor β (Tgf‐β), while decreasing proinflammatory factors Tnf‐α, Il‐1β, and Il‐6 [135]. This evidence concerns the gene IL6 and brain infarction.