Similarly, the TRPV1 agonist capsaicin suppresses the expression of NLRP3, cysteinyl aspartate‐specific protease‐1 (caspase‐1), and IL‐1β by anti‐autophagy in microglia after OGD/R, whereas the TRPV1 antagonist 5′‐iodoresiniferatoxin (iRTX) exhibits the opposite effect [165], suggesting that TRPV1 modulates autophagy‐mediated NLRP3 inflammatory effects may be a key neuroprotective target in ischemic stroke. The gene discussed is NLRP3; the disease is ischemic stroke.