TRPM2 is activated in the 1‐methyl‐4‐phenylpyridinium (MPTP)‐induced PD mouse model, and deletion of Trpm2 in microglia or blockade of TRPM2 channel activity using ACA and 2‐APB suppresses inflammatory cytokines (IL‐1β, TNF‐α, IL‐6) responses and reduces MPTP‐induced damage [67]. The gene discussed is IL1B; the disease is Parkinson disease.