Emerging evidence suggests that specific members of TRP channels, including TRPA1, TRPC1, TRPC3, TRPC6, TRPM2, TRPM4, TRPM7, TRPM8, TRPV1, TRPV2, and TRPV4, are implicated in neuroinflammatory processes and play crucial roles in the pathophysiology of neuropathic pain, migraine, stroke, MS, AD, PD, ASD, epilepsy, anxiety, and depression (Figure 3 and Tables 1, 2, 3, 4, 5). The gene discussed is TRPV1; the disease is major depressive disorder.