TRPV4 and major depressive disorder: The TRPV4 inhibitor HC‐067047 or hippocampal Trpv4 knockdown alleviates depression‐like behaviors by reducing astrocyte and microglia activation, with suppressed CaMKII‐NLRP3 inflammasome expression and serum IL‐6, TNF‐α, and IL‐1β levels, and increased neurogenesis in the hippocampus [146].