NOS1 and migraine disorder: Similarly, the CB agonist anandamide (AEA) decreases the expression of TRPV1, nitric oxide synthase (nNOS), NF‐κB, and COX‐2 in the upper cervical spinal cord of the nitroglycerin‐induced migraine rat model [95], indicating TRPV1 may combine with the cannabinoid receptor in modulating inflammation in migraine pathogenesis.