TRPV1 and tauopathy: Moreover, in the APOE ε4‐related tauopathy mouse model, microglial TRPV1 loss worsens glial inflammation, T cell infiltration, and memory impairments, whereas capsaicin‐mediated TRPV1‐Ca2+ signaling blocks SREBP2‐driven cholesterol biosynthesis and effectively suppresses the excessive neuroinflammation and neurodegeneration [111].