AG490, a TRPM2 inhibitor, restores motor behavior by reverting the morphology of microglia and astrocytes to normal states, with normalization of mRNA expressions of proinflammatory (iNOS and CD86) and anti‐inflammatory mediators (Arginase1) in the striatum of the 6‐OHDA‐induced PD mouse model [68]. Here, NOS2 is linked to Parkinson disease.