In RANKL 643C/T, the CT genotype and minor allele T had greater frequences in CF and DP with neuropathy compared to HP.47 Furthermore, RANKL 693C/G had an increased frequency of the homozygous mutant GG and minor allele G in DP with neuropathy and CF compared with HP. Here, TNFSF11 is linked to cystic fibrosis.