IL-1β is a pro-inflammatory cytokine associated with cartilage destruction in osteoarthritis, whose effect is compounded by TNF.24 Plasma IL-1RA levels are elevated in CF and DP compared with HP at inclusion and after 2 years.16 However, IL-1RA levels are higher in CF at 4 months after inclusion compared to at inclusion. This evidence concerns the gene IL1B and cystic fibrosis.