Importantly, combined IGF2BP2 knockdown and RSL3 treatment further exacerbated these effects (Figures 3D–G and S8A–D), indicating that IGF2BP2 depletion sensitises CRC cells to RSL3‐induced ferroptosis by impairing the Nrf2–GPX4 antioxidant pathway. Here, IGF2BP2 is linked to colorectal carcinoma.