For instance, lactylation of METTL16 enhances its m6A modification activity on FDX1 mRNA, promoting cuproptosis in gastric cancer,54 while in hepatic stellate cells, IGF2BP2 knockdown has demonstrated to reduce both global lactylation and H3K18la levels,55 suggesting IGF2BP2 may both undergo and potentially influence lactylation dynamics. This evidence concerns the gene FDX1 and gastric cancer.