For example, ALKBH5 knockdown increased Nrf2 expression in hypopharyngeal squamous cell carcinoma through an m6A–IGF2BP2‐dependent mechanism, thereby enhancing cancer cell ferroptosis resistance,33 consistent with our findings that IGF2BP2 depletion sensitises CRC cells to ferroptosis and impedes tumour progression. This evidence concerns the gene ALKBH5 and cancer.