TG and thyroid crisis: For patients who cannot tolerate drugs or who have failed drug therapy, alternative treatments need to be considered, including the use of extracorporeal systems such as continuous renal replacement therapy, veno-arterial extracorporeal membrane oxygenation, and therapeutic plasma exchange.[17,40–42] Successful treatment of thyroid storm depends on early inhibition of thyroid hormone secretion and suppression of peripheral T4 to T3 transformation.