GDF15 and cancer: For example, this work shows that subjects with higher DNAm-predicted GDF15 exhibit distinct inflammatory signatures, potentially affecting their susceptibility to cardiovascular disease and cancer.[32] Regulatory T cells, identified as another key subtype in this analysis, are crucial for sustaining immunological homeostasis and regulating inflammatory cascades.[33] Subsequent research ought to delineate the primary transcription factors governing the differentiation and function of these inflammation-related cellular subsets, particularly regarding GDF15 modulation.