NAXE and Mental deterioration: APOA1BP, also known as NAXE, encodes an enzyme with dual functions critical for cellular homeostasis.[36] Clinical observations of APOA1BP deficiency, particularly in pediatric populations, reveal severe neurological and systemic manifestations, including ataxia, cognitive decline, motor disturbances, psychiatric disorders, and pellagra-like skin lesions.[37–39] In this study, the GSE98937 dataset revealed APOA1BP as a significantly down-expressed DEG with diagnostic potential for SZ (AUC = 0.76).