BAK1 and hematologic disorder: Its mechanism of action involves mimicking the function of BH3-only proteins, competitively binding to the Bcl-2 protein, thereby inhibiting Bcl-2’s anti-apoptotic function.[15,16] The Bcl-2 protein is highly expressed in many hematological malignancies, protecting cells from apoptosis by preventing the activation of BAX and BAK proteins.