SLC6A3 and major depressive disorder: This study indicates that propofol directly binds to the dopamine transporter to block its transport function, thereby regulating dopamine concentrations in neuronal synapses.[8] Furthermore, propofol participates in regulating depression-related anhedonic-like behaviors by promoting the activity of neurons expressing D1R in the striatum (NAC D1-MSNs).[8] In a mouse model of chronic stress induction, propofol reversed long-term stress-induced anhedonic behavior, which was also attributed to the activation of D1-MSNs.[8]