The gender-dependent association between log2-ferritin and in-hospital mortality as well as 90-day mortality, significant in males, may reflect gender-related differences in immune responses and inflammation in AP.[44,45] Elevated transferrin reduce in-hospital mortality risk in high BMI patients, highlighting its dual role as an acute-phase reactant and obesity-related oxidative mediator.[46,47] The observed ethnic differences in the protective effects of transferrin and TIBC should be interpreted cautiously, as they are likely confounded by baseline imbalances between the groups. Here, TF is linked to Obesity.