CDK1 and hepatocellular carcinoma: Cyclin-dependent kinase 1 (CDK1), a key cell cycle protein, is involved in HBV-associated HCC.[57] In normal cells, the expression of CDK1 is restrictively regulated, however, in cancer, its activity is enhanced in various ways.[58] Therefore, inhibition of CDK1 expression can be considered as a strategy to suppress the proliferation of tumor cells.