Further studies have shown that quercetin, in combination with Se nanoparticles, could be effective in overcoming resistance to SFB by modulating oxidative stress, inflammatory state, and the p53/β-catenin/cyclin D oncogenic axis pathway to inhibit HCC progression in rats.[117] Wnt/β-catenin signaling governs vital embryonic and somatic processes. The gene discussed is TP53; the disease is hepatocellular carcinoma.