Regarding the downstream of the PI3K/Akt pathway, it has been reported that quercetin can inhibit cancer aggressiveness by reversing EMT through downregulation of epidermal growth factor receptor and its downstream PI3K/Akt pathway.[105] Figure 4 shows the various mechanisms by which quercetin suppresses the metastasis and invasion of liver cancer cells. The gene discussed is AKT1; the disease is cancer.