Caspase-8 is an initiator of the exogenous apoptotic cascade,[78] and the inhibition of caspase-8 activity has been reported in HCC.[79] In Salama study quercetin reduced caspase-8 mRNA levels in both protected and treated groups, suggesting that quercetin may not be directly involved in the exogenous apoptotic pathway.[39]. Here, CASP8 is linked to hepatocellular carcinoma.