Studies on the anti-liver cancer activity and molecular mechanism of the Yiqi Jianpi Jiedu formula have found that it mainly inhibits the proliferation, migration, and invasion of liver cancer cells through a variety of bioactive components, such as quercetin, multiple pathways, and targets defined by the PI3K/Akt pathway, β-catenin, MAPK3, and RHOA. Here, MAPK3 is linked to liver cancer.