JAK2 and hepatocellular carcinoma: This pathway has been shown to play an important role in cancer cachexia and is significantly associated with the proliferation, invasion, and migration of cancer cells.[60,61] IL-6, a major inflammatory mediator in the tumor microenvironment (TME), acts directly on tumor cells to induce the expression of STAT3 target genes, which encode proteins that drive tumor proliferation.[62] Wu et al[35] found through the cell counting kit-8 test that quercetin inhibits HCC cell proliferation in a time- and dose-dependent manner, which is related to the IL-6/JAK2/STAT3 signaling pathway.