Se deficiency has been associated with various diseases and many types of cancers, including HCC.[120] Meanwhile, researchers found that Se nanoparticles were able to overcome SFB resistance by modulating apoptosis and mTOR/NF-κB signaling in a rat model of HCC.[121] Mohamed et al[117] suggested that the combination of quercetin and Se nanoparticles resulted in a higher return to normal levels of AFP and more normal histopathological features than compared to the drug alone. The gene discussed is AFP; the disease is hepatocellular carcinoma.