Overall, our MR and colocalization analyses identified 15 candidate target genes – BLVRA, SLC9A3, LYZ, SRPK1, HOXA5, LYVE1, S100A9, ADORA1, RPL13, IL7R, SLFN11, SHMT1, CLN8, TOP1MT, and LPAR5 – that indicate a shared genetic susceptibility to childhood asthma.For more details, see Supplementary Material 4, Supplemental Digital Content, https://links.lww.com/MD/Q969. This evidence concerns the gene LYZ and childhood onset asthma.