We identified 35 druggable genes significantly associated with childhood asthma (including BLVRA, SLC9A3, LYZ, SRPK1, HOXA5, LYVE1, S100A9, ADORA1, RPL13, IL7R, SLFN11, SHMT1, CLN8, TOP1MT, LPAR5, RNASET2, ANK1, H6PD, DSP, CDC25B, VWF, ITK, CACNG6, ITGB7, S100A8, ADAM12, ST14, BMP6, HK2, SYK, ABCA1, ULK4, KBTBD2, SLCO4C1), with BLVRA showing promise as a target. This evidence concerns the gene SHMT1 and childhood onset asthma.