INS and diabetes mellitus: Results show that the use of exogenous insulin (ukb-b-7350) through diabetes (ebi-a-GCST90013891) for OA of the intermediary effect is 12.68639, the mediation effect of 74.26% (12.68639/ −17.08472 | | * 100%); The use of exogenous insulin (ukb-b-7350) by smoking (ieu-b-4857) for the mediation effect of OA is 26.83313, the mediation effect of 70.11% (26.83313/ −38.27482 | | * 100%); The use of exogenous insulin (ukb-b-7350) by smoking (ukb-b-2047) for the mediation effect of OA is 4.4753, the mediation effect of 43.34% (4.4753/ −10.32532 | | * 100%).