INS and diabetes mellitus: The results showed that model 1 took diabetes (ebi-a-GCST90013891) and insulin (ukb-b-7350) as exposure, and the results showed that after removing the effect of diabetes, the use of exogenous insulin (ukb-b-7350) was significantly higher than that of exogenous insulin (ukb-b-7350) still had a direct effect on OA (ieu-a-1169) (P < .05).