ELISA assays revealed significantly elevated levels of M1 macrophage-associated cytokines (TNF-α and IL-6) and decreased M2 macrophage-associated cytokines (IL-10 and TGF-β) levels in patients with ITP compared with Ctrls (Fig. 1A–D). The gene discussed is IL10; the disease is autoimmune thrombocytopenic purpura.