In human A549 cells, both bovine and human Mx1 displayed antiviral activity against an r-Tx/37-B3.13 reporter virus in a single-cycle infection relative to a chicken Mx1 control (lacking antiviral activity85–87) by approximately 3-fold, while PR8 was affected by less than two-fold relative to the chicken Mx1 control cells (Fig. 6d and Fig. S7). The gene discussed is MX1; the disease is infection.