We then searched for common hits between the screens and identified only two candidate host factors involved in SAFV-3 infection: PA2G4 (proliferation-associated 2G4), an important translation initiation factor for the type II internal ribosome entry site (IRES) of foot-and-mouth disease virus (FMDV)21 and cardioviruses22; and SLC35B2 (solute carrier family 35 member B2), which is responsible for transporting the sulfate donor 3-phosphoadenosine-5-phosphosulfate (Fig. 1a). This evidence concerns the gene SLC35B2 and infection.