These findings bring a new insight on the major role of GRP94 in cancer but also in a variety of diseases involving proteins processed by furin, including growth factors such as insulin growth factors and their receptors, metalloproteinases like MMP2 or viral glycoproteins such as the SARS-CoV-2 Spike glycoprotein [14, 22, 25]. This evidence concerns the gene HSP90B1 and cancer.