Xia, S. et al. reported that Wnt2 overexpression protected against mitochondrial dysfunction and oxidative stress in Parkinson’s disease Drosophila model.15 Given the central role of mitochondrial dysfunction and oxidative stress in myocardial I/R injury, we speculate Wnt2 could protect against myocardial I/R injury by regulation of mitochondrial function. Here, WNT2 is linked to Parkinson disease.