Nap1L1 belongs to the family of nucleosome assembly proteins, which contribute to cell DNA replication and chromatin regulation by participating in the assembly and disassembly of nucleosomes.45 Nap1L1 is widely reported to be increased in multiple tumors and stimulates tumor progression, and elevated Nap1L1 is considered an unfavorable prognostic biomarker for several various tumors.46,47 Our previous study revealed that the downregulation of Nap1L1 promotes cardiomyocyte differentiation via the regulation of notch signaling in murine iPSCs.18 Cheng Lv et al. reported that NAP1L1p. The gene discussed is NAP1L1; the disease is neoplasm.