FZD9 and colitis: It has been reported that Wnt2 inhibits enteric bacterium-induced inflammation in intestinal epithelial cells.51 Restoring Wnt2-FZD9-β-catenin signaling reduces colitis severity in ulcerative colitis (UC) in murine models.52 During cerebral I/R, the activation of Wnt/β-catenin signaling induces the proliferation of vascular endothelial cells to promote angiogenesis.10 Whether Wnt2 protects the heart from I/R through the inhibition of inflammation or the activation of angiogenesis needs further study.