PRDM9 and glioblastoma: We leveraged parallel H3K36me3 ChIP-seq data, and overlapped intergenic H3K4me3 and H3K36me3 peaks with the PRDM9 motif (Fig. 6f) to confirm PRDM9 activity in glioblastoma, as the co-occurrence of H3K4me3, H3K36me3 and PRDM9 motif in intergenic regions is uniquely associated with PRDM940.