PRSS56 and Kyphoscoliosis: We identified 11.62% (5/43) and 12.82% (5/39) of Prss56-Nf1fl/fl, 14.28% (3/21), and 17.25% (5/29) of Prss56-Nf1fl/- mutant mice manifesting kyphoscoliosis at 12 and 14-20 months of age, respectively (Fig. S2c).