Scoliosis was identified in 18.6% (8/43) and 30.77% (12/39) of Prss56-Nf1fl/fl and 33.30% (7/21) and 27.8% (8/29) of Prss56-Nf1fl/- mutant mice at 12 and 14-20 months of age, respectively (Fig. S1b). The gene discussed is PRSS56; the disease is scoliosis.