The findings revealed a notable downregulation of IL‐6, IL‐8, and IL‐1β (p < 0.05) in the CS‐treated COPD mouse model, accompanied by an upregulation of IFN‐γ, in comparison to both wild‐type mice and the untreated COPD mouse model [35]. Here, CXCL8 is linked to chronic obstructive pulmonary disease.