FUS and amyotrophic lateral sclerosis: For instance, we note that actin stress fiber gene Limch1 is rhythmically spliced in both cholinergic neurons and an overlapping target of rhythmically expressed ALS-linked RBPs FUS, TAF15, and hnRNPA2B1 (Table S7) (Ibrahim et al, 2013; Nakaya et al, 2013; Martinez et al, 2016), suggesting that one or more of these RBPs may directly regulate its RNA processing and protein function in a time-of-day-dependent manner.