Genetic studies have revealed associations between ALS and mutations in genes encoding a number of RBPs, including TDP-43, FUS, ATXN2, TAF15, EWSR1, hnRNPA1, hnRNPA2B1, MATR3, and TIA1 (Kapeli et al, 2017; Zhao et al, 2018). Here, TARDBP is linked to amyotrophic lateral sclerosis.