For example, ALS-linked FUS mutations were found to alter FUS regulation of a motor neuron survival factor SMN and inhibit its transport to axons (Groen et al, 2013), as well as impair RNP granule function by inducing phase transitions (Murakami et al, 2015; Patel et al, 2015). Here, RNPC3 is linked to amyotrophic lateral sclerosis.