For example, many of the proteins that copurify with TDP-43 are associated with RNA splicing and translation (Freibaum et al, 2010), and ALS-linked mutations in TDP-43 were shown to impair mRNA axonal transport and alter the fluid properties of TDP-43–positive liquid droplets (Alami et al, 2014; Schmidt & Rohatgi, 2016). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.