SRSF7 and amyotrophic lateral sclerosis: Our analysis further revealed that ALS-linked RBP serine/arginine-rich splicing factor 7 (SRSF7) was alternatively spliced by A5SS in cholinergic neurons with Bmal1 deletion during the dark period (Fig 7G; Table S6D), with changes corresponding to an increase in the inclusion level of an exon 5 coding variant in the human genome (GRCh38.p14; ENST00000409276.5; chr2:38744893-38751358) (Dyer et al, 2025).