Furthermore, ALS-linked mutations in TAF15 were found to increase the number of TAF15-positive axonal and dendritic stress granules (Couthouis et al, 2011), and inhibition of TAF15 methylation resulted in the accumulation of TAF15 in TIA1-positive stress granules (Jobert et al, 2009). Here, TIA1 is linked to amyotrophic lateral sclerosis.