Given that we did not observe differential mRNA expression of Atxn2 (or other rhythmically expressed ALS-linked RBP transcripts) with cholinergic neuron-specific Bmal1 deletion, it is likely that this decrease in ATXN2 expression is a result of clock-driven post-translational events. The gene discussed is ATXN2; the disease is amyotrophic lateral sclerosis.