TLR4, a significant pattern recognition receptor, influences CRC development through its recognition of lipopolysaccharides (LPS) from intratumoral microbiome [99–101] Microorganisms within tumors, such as F. nucleatum, Bacteroides fragilis, and Campylobacter jujuni, activate TLR4 via LPS secretion. The gene discussed is TLR4; the disease is colorectal carcinoma.