POU3F1 and rheumatoid arthritis: For example, an RA-associated locus near POU3F1, a neuronal transcription factor that is also induced by interferon (Hofmann et al., 2010), colocalized with a distal eQTL located about 126 kb upstream of its promoter, after meta-analysis strengthened the eQTL association (p<10–10; Figure 4C).