SCFA activation of GPRs promotes secretion of GLP‐1 and peptide YY (PYY) by intestinal L‐cells in diabetic rats, which have hypoglycemic functions and are involved in T2DM‐related immunomodulation, thereby improving diabetic symptoms (Yao et al. 2020; Tan et al. 2014; Remely et al. 2014; Sun et al. 2017). This evidence concerns the gene GLP1R and type 2 diabetes mellitus.