Faecal bacteria from patients with T2DM have been shown to cause abnormalities in glucose and lipid metabolism in normoglycemic mice (Hu 2016), impairing insulin tolerance and oral glucose tolerance while altering the composition of the gut microbiota, leading to a significant reduction in Prevotella at the genus level (Wang, Wang, et al. 2022). The gene discussed is INS; the disease is type 2 diabetes mellitus.