,37 Moreover, we demonstrated higher TGM2 induction (Figure S1I) with the IBD fecal content in Caco-2 cells, which we have shown to be upregulated in biospecimens from human IBD datasets,10,38and we, along with others, have linked this induction to altered metabolic and mitochondrial functions.38 This evidence concerns the gene TGM2 and inflammatory bowel disease.