Nine days of chronic intermittent administration of CGRP led to significantly increased avoidance of melanopsin stimulation (0.58 ± 0.08, n = 21) as compared to Veh administration (0.26 ± 0.09, n = 22) (F (1, 41) = 5.70, p = 0.022).<h4>Conclusions</h4>Our findings support a key role for the ipRGCs in the production of photophobia. The gene discussed is OPN4; the disease is Photophobia.