The role of human endogenous retrovirus K (HERV-K, HML-2) in glioblastoma has been experimentally demonstrated: CRISPR interference targeting HML-2 LTR5Hs elements in patient-derived glioblastoma neurospheres led to marked reductions in neurosphere formation, OCT4 and Nestin expression, and tumorigenicity in intracranial xenografts, resulting in prolonged survival. This evidence concerns the gene CLEC10A and glioblastoma.