Studies have confirmed that nasal and airway epithelial cells express the SCFA receptors GPR41 and GPR43, and one study demonstrated that SCFAs can activate these receptors to induce tissue plasminogen activator (t-PA) expression, holding therapeutic potential for reducing fibrin deposition in nasal polyps (Wu et al., 2024). The gene discussed is FFAR3; the disease is nasal cavity polyp.