IL10 and hepatocellular carcinoma: Moreover, Prohep further inhibits HCC growth and metastasis by upregulating anti-inflammatory cytokine expression—IL-10, IL-13, and IL-27 and inhibiting angiogenesis-related factor expression—vascular endothelial growth factor A, fms related receptor tyrosine kinase 1, angiopoietin 2, and kinase insert domain receptor (Li et al., 2016).