The janus kinase/signal transducer and activator of transcription signaling pathway, pivotal in HCC cell proliferation, survival, migration, and immune evasion, activates signal transducer and activator of transcription protein phosphorylation by regulating interactions between cytokine receptors (e.g., IL-6, IL-10, and IL-12) and janus kinase kinases. Here, IL10 is linked to hepatocellular carcinoma.