NR1H4 and hepatocellular carcinoma: FXR-specific agonists GW4064 and obeticholic acid can markedly ameliorate mucosal damage, increased ileal barrier permeability, bacterial overgrowth, and bacterial translocation in rodent models (Verbeke et al., 2015; Úbeda et al., 2016), potentially serving as therapeutic agents for HCC prevention.