Furthermore, non-alcoholic steatohepatitis-mediated HCC mouse models demonstrate not only alterations in the intrahepatic immunosuppressive landscape but also an increased number of myeloid-derived suppressor cells (MDSCs) and a concomitant reduction in CD4 + and CD8 + T cell counts, thereby exacerbating liver injury and HCC formation (Schneider et al., 2022). The gene discussed is CD8A; the disease is hepatocellular carcinoma.