NGF and neoplasm: This high-risk window coincides with three fundamental biological transitions: (1) the decline of maternal antibodies coupled with autoimmune system maturation (26); (2) accelerated sympathetic nervous system development accompanied by dynamic nerve growth factor (NGF) and receptor expression changes (27); and (3) stabilization of gut microbiota colonization, potentially influencing the tumor microenvironment through microbiota-immune-neural crosstalk (28, 29).