Our patient was found to have two variants associated with intrahepatic cholestasis: a likely pathogenic variant (ACMG class 4) in the ABCB11 gene, linked to PFIC2, and a variant of uncertain significance (ACMG class 3) in the ATP8B1 gene, which is associated with PFIC1. This evidence concerns the gene ATP8B1 and intrahepatic cholestasis.