Furthermore, in fluorescence staining, we observed the effects of CLEC4G and Wnt/β‐catenin on the expression of PD-1 in PLC/PRF/5‐R, which once again proves that CLEC4G modulates the immune escape behavior of HCC through the Wnt/β‐catenin pathway. This evidence concerns the gene CLEC4G and hepatocellular carcinoma.