In chronic myeloid leukemia (CML) cells, they showed that TRPM7 kinase regulates AKT and mothers against decapentaplegic homolog 2 (SMAD2) pathways leading to modulated cyclooxygenase-2 (COX-2) expression [24]. This evidence concerns the gene TRPM7 and chronic myelogenous leukemia, BCR-ABL1 positive.