For example, the CARM1–USP9X–OGT axis enhances glycolysis and the Warburg effect, promoting tumor growth [225]; O‐GlcNAcylation of SMAD4 activates the TGF‐β signaling pathway to induce epithelial–mesenchymal transition (EMT) [226]; and the IL‐6/STAT3 pathway, regulated by O‐GlcNAcylation, amplifies inflammatory responses, further driving invasion and metastasis [227]. Here, TGFB1 is linked to neoplasm.