For example, the Thr556 residue of the chromatin remodeler MORC2 can be O‐GlcNAcylated, and modified MORC2 promotes the expression of TGF‐β1 downstream target genes CTGF and SNAIL, both of which are critical for breast cancer invasion and metastasis [263]. The gene discussed is TGFB1; the disease is breast carcinoma.