The Warburg effect—enhanced aerobic glycolysis—commonly observed in CRC is also regulated by O‐GlcNAcylation [250, 251]: OGT mediates glycosylation of c‐Myc at Ser415, enhancing its stability and activity, which upregulates PDK2, suppresses mitochondrial pyruvate metabolism and ROS generation, ultimately reinforcing glycolysis, inhibiting the tricarboxylic acid cycle, and promoting tumor cell proliferation [252]. The gene discussed is OGT; the disease is neoplasm.