Finally, studies have revealed that SET domain‐containing protein 5 in CRC upregulates the expression of CSC markers such as ESRRB, CD133, and KLF4 by facilitating OGT‐mediated O‐GlcNAcylation of RNAP II, endowing tumor cells with stem‐like properties—a process dependent on O‐GlcNAcylation [262]. This evidence concerns the gene OGT and neoplasm.