Thrombophilia is a major predisposing risk factor for BCS, encompassing both inherited causes such as protein C, protein S, antithrombin III deficiency, Factor V Leiden mutation, and acquired conditions including antiphospholipid syndrome, hypercoagulable states, and myeloproliferative disorder [6]. Here, F5 is linked to hyperinsulinemic hypoglycemia, familial, 4.