PADI4 and neoplasm: In tumor-associated neutrophils (TANs), abnormal methylation of IL-8, CXCR2, and PAD4 mediated by DNMT1 and DNMT3A drives N2 polarization, promoting angiogenesis and immune suppression; activation of TET3 can revert this phenotype to N1, enhancing reactive oxygen species-dependent tumor-killing effects (155).