(24) found that the percentages of PD-1+ CD8+ T cells, TIM-3+ CD8+ T cells, and LAG-3+ CD8+ T cells were significantly elevated in patients with HLH, and the proportion of PD-1+TIM-3+ CD8+ T cells was also increased, consistent with our result of an increased proportion of PD-1+TIGIT+CD8+ T cells. The gene discussed is CD8A; the disease is hemophagocytic syndrome.