PRDX6 and acute respiratory distress syndrome: In addition, Liang et al. (124) revealed that the RNA methyltransferase ZC3H13 enhanced m^6A methylation of PRDX6 mRNA in a YTHDF2-dependent manner, thereby modulating PRDX6 expression, regulating the p53/SLC7A11 axis, and promoting ferroptosis in AMs, which ultimately exacerbated sepsis-induced ALI.