Taken together, our single-cell RNA expression analysis affirmed that SELPLG and SH2D2A are differentially regulated in single tumor-infiltrating L1CAM-CAR T cells, suggesting a functional role, while TIAM2, CORO1B and MYH10 do not seem to influence L1CAM-CAR T cell migration. The gene discussed is SH2D2A; the disease is neoplasm.