Cytotoxicity to SK-N-BE (2) neuroblastoma cells (challenged 24h in coculture) was comparable among L1CAM-CAR T cells, L1CAM-CAR T cells co-transduced with GFP-tagged SH2D2A or co-transduced with GFP alone (mean lysis: L1CAM-CAR=77.18%, L1CAM-CAR co-transduced with GFP-tagged SH2D2A = 66.3%, L1CAM-CAR cotransduced with GFP = 68.19%; Figure 4E). Here, SH2D2A is linked to neuroblastoma.