SH2D2A encodes the T cell-specific adaptor protein (TSAd), known to act within the CXCR4/CXCL12 signaling axis and to play a role in laminin-dependent T cell migration, assisting attachment to laminin present in tumor stroma and activating the focal adhesion kinase, a central regulator of cell migration, adhesion and survival (31, 32). Here, CXCL12 is linked to neoplasm.