Figure 12F displays the top four most significant pathways in terms of both activation and inhibition, including autoimmune thyroid disease, asthma, allograft rejection, the intestinal immune network for IgA production, the estrogen signaling pathway, human papillomavirus infection, the PI3K-Akt signaling pathway, and Staphylococcus aureus infection. This evidence concerns the gene PIK3CA and autoimmune thyroid disease.