Whereas Class2 uniquely included pathways related to bacterial infections (e.g., E. coli, Salmonella) together with actin-cytoskeleton and T-cell modules (e.g., ACTB, PFN1, RAC2, PIK3CD, CD3D/CD3G, STING1, TRADD, CASP8, BCL2, HLA-F). The gene discussed is CASP8; the disease is bacterial infectious disease.