ATG5 and COVID-19: In hospitalized patients, dynamic alterations of sequestosome 1 (p62/SQSTM1) and microtubule-associated proteins 1A/1B light chain 3B/autophagy-related 5 (LC3/ATG5) have been observed alongside cytokine signatures, consistent with systemic perturbation of autophagy in severe COVID-19 (50).