DOCK8 and Autoimmunity: Their distribution varied substantially across genetic entities: CD3γ, Dedicator of Cytokinesis 8 (DOCK8), and Helios deficiencies were consistently associated with high frequencies of autoimmunity, whereas other causes, such as MHC class II and F-BAR domain-only protein 1 (FCHO1) deficiencies, were only rarely linked to immune dysregulation (Table 2).