In murine MASLD models, T cell-specific nuclear receptor subfamily 4 group a member 1/2 (Nr4a1/2) double knockout leads to a significant expansion of tissue-resident Tregs (CD44+CD62L–CD69+), accompanied by reduced levels of pro-inflammatory cytokines such as IFN-γ and IL-17, and diminished activation of inflammatory Macrophages (92). The gene discussed is IL17A; the disease is metabolic dysfunction-associated steatotic liver disease.