In MASLD mouse models, depletion of c-type lectin domain family 4, member f (Clec4F+) T-cell Immunoglobulin and Mucin domain-containing protein 4 (Tim4+) KCs and expansion of MDMs subsets, including Clec4F–Tim4– and Clec4F+Tim4– populations resembling KCs, are observed. The gene discussed is TBCE; the disease is metabolic dysfunction-associated steatotic liver disease.