C5AR1 and pemphigus foliaceus: A comprehensive understanding of the regulatory networks mediated by neutrophils in PF is of dual importance: firstly, neutrophil counts and levels of NETs may serve as prognostic biomarkers, such as the neutrophil-lymphocyte ratio (NLR) (25); secondly, targeting neutrophil-associated pathways—such as inhibiting NETs formation (24), blocking complement component 5a receptor 1(C5aR1) signaling—offers potential as an innovative therapeutic strategy (26).